PyAesCrypt

import pyAesCrypt
# encryption/decryption buffer size - 64K
bufferSize = 64 * 1024
password = "foopassword"
# encrypt
pyAesCrypt.encryptFile("data.txt", "data.txt.aes", password, bufferSize)
# decrypt
pyAesCrypt.decryptFile("data.txt.aes", "dataout.txt", password, bufferSize)

Source: pypi.org

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